Figure 7.

Disruption of thyroid hormone signaling prevents the effects of nervous system-specific JNK1 deficiency on HFD-induced weight gain. (A) N^KO and N^WT mice were treated with PTU in the drinking water. The mice were divided into chow-fed (ND) and HFD-fed groups after 2 wk, and then maintained for an additional 10 wk. The body weight of the mice is presented. No statistically significant differences between N^KO and N^WT mice were detected (P > 0.05). (B) Chow-fed (ND) and HFD-fed N^KO and N^WT mice were examined after 12 wk of treatment with PTU. The blood glucose concentration in fed and overnight fasted mice, body temperature, and the blood hormone (insulin, leptin, and resistin) concentrations are presented. No significant differences between N^KO and N^WT mice were detected (P > 0.05). (C) Glucose tolerance tests (GTT) on PTU-treated chow-fed (ND) and HFD-fed N^KO and N^WT mice are presented. No significant differences between N^KO and N^WT mice were detected (P > 0.05). Insulin tolerance tests (ITT) on PTU-treated HFD-fed N^KO and N^WT mice are presented. No significant differences between N^KO and N^WT mice were detected (P > 0.05).