Table 1.

Pharmacokinetic parameters of ciprofloxacin in goat (n = 6) following a single intravenous administration with 4 mg/kg body weight

C^o_p-Serum drug concentration at t=0; α and β-hybrid rate constants represent the slopes of distribution and elimination phases, respectively; t_1/2α-distribution half-lives; t_1/2β-elimination half-lives; k_el-first order elimination rate constant, Vc-volume of distribution from central compartment; VdSS-volume of distribution at steady-state; K₁₂-rate constant of transfer of drug from central compartment into the tissue compartment; K₂₁-rate constant of transfer of drug from tissue compartment into the central compartment; AUC_0→12-Area under the serum concentration vs. time curve from 0 to 12 h; AUC_0→∞-Area under the serum concentration vs. time curve from 0 to ∞; AUMC area under the first moment curve; MRT-mean residence time; Cl_B-total body clearance; r²-Correlation coefficient fit curve of serum concentration vs time profile.