Skip to main content
. Author manuscript; available in PMC: 2011 Feb 23.
Published in final edited form as: Curr Biol. 2010 Jan 20:nihpa168171. doi: 10.1016/j.cub.2009.12.033

Figure 1.

Figure 1

mad2Δ shortens checkpoint-mediated cell cycle delay after induction of an unrepaired DSB. A) Induction of an irreparable DSB causes a delay in the cell cycle equivalent to 6 doubling times in wild type cells, which is fully eliminated by mec1Δ. mad2Δ reduces arrest in chk1Δ and is epistatic to rad53Δ. B) Response to a DSB in Chr6 is similar to that on Chr3, while a break on Chr11, where the DSB is 200 kb further from its centromere, provokes a significantly shorter Mad2-dependent arrest.