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A. Schematic of cp-p300-F HAT (circularly permuted Y1467F) showing site-specific acetylations (blue, green) on the engineered loop (colored circles). The 7-aa flexible spacer is shown in red and the gray circles are the C-terminus of the recombinant moiety. B. SDSPAGE of cp-p300-F HATs. C. Representative fluorescence plot of acetonyl-CoA binding to cp-p300-F-6Ac. D. Dissociation constants of acetonyl-CoA with cp-p300-Fs.
