Table 1.
Characteristics of the 30 patients with Gram-negative VAP*
| Parameter | Value |
|---|---|
| Age (year), median (IQR) | 49 (33-57) |
| Sex, n (%) | |
| Male | 23 (77) |
| Female | 7 (23) |
| Body height at inclusion, cm, median (IQR) | 177 (167.9-182.9) |
| Body weight at inclusion, kg, median (IQR) | 84 (78-91) |
| Primary reason for MV, n (%) | |
| Trauma | 13 (44) |
| Cardiac failure | 4 (13) |
| Postoperative respiratory failure | 4 (13) |
| Acute respiratory distress syndrome | 3 (10) |
| Coma/CNS disease | 3 (10) |
| Sepsis | 2 (7) |
| Pulmonary embolism | 1 (3) |
| Tracheotomy, n (%) | 7 (23) |
| Septic shock at inclusion, n (%) | 2 (7) |
| Vasopressor use at inclusion, n (%) | 5 (17) |
| MV duration before VAP onset, days, median (IQR) | 9 (5-11) |
| Acute respiratory distress syndrome at inclusion, n (%) | 5 (17) |
| PaO2/FIO2 ratio upon inclusion, mmHg, median (IQR) | 210 (171-281) |
*Two of these patients were not included in the pharmacokinetic analysis because they did not received at least three full days of study medication.
CNS = central nervous system; FiO2 = fraction of inspired oxygen; IQR = interquartile range; MV = mechanical ventilation; PaO2 = partial pressure of arterial oxygen; VAP = ventilator-associated pneumonia;