Table 4.

Predictive value of the cuff leak test

		Cuff leak cut off
Author	Year	Volume (ml)	Percentage of tidal volumea	Outcome	Sensitivity	Specificity	PPV	NPV
Miller and Cole [27]	1996	110		PES	0.67	0.99	0.80	0.98
Jaber and colleagues[30]	2003	130	12	PES	0.85	0.95	0.69	0.98
de Bast and colleagues [36]	2002		15.5	Reintubation	0.75	0.72	0.25	0.96
Sandhu and colleagues [26]	2000		10.0	PES or reintubation	0.54	0.96	0.64	0.94
Wang and colleagues [14]	2007	88		PES			0.55	0.91
Maury and colleagues [25]	2004	0		PES	1.00	0.80	0.15	1.00
Chung and colleagues [55]	2006	140		Laryngeal edema	0.89	0.90	0.84	0.93
Engoren [56]	1999	110		PES	0.00	0.96	0.00	0.99
Kriner and colleagues [8]	2005	110		PES	0.50	0.84	0.12	0.97
Cheng and colleagues [3]	2006		18.0	PES	0.85	0.72	0.21	0.98

NPV, negative predictive value; PPV, positive predictive value; PES, post-extubation stridor. ^aCuff leak volume as a percentage of inspiratory or expiratory tidal volume.