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. 2009 Dec 3;13(6):R193. doi: 10.1186/cc8191

Table 1.

Patient characteristics

Group 1
4 L to 2 L/h
Group 2
2 L to 4 L/h
n = 7 N = 7
Age (years) 65 (38-69) 65 (60-75)
Male/female (n) 5/2 5/2
Body weight (kg) 75 (72-80) 75 (60-98)
Cause of ARF (n)
 sepsis 5 5
 cardiogenic shock 2 1
 liver failure 1
APACHE II 35 (29-38) 25 (19-31) 0.07
APACHE II predicted mortality (%) 85 (72-88) 56 (21-73) 0.10
APACHE III 128 (104-138) 94 (50-148) 0.18
SOFA start CVVH 14 (11-15) 9 (5-9) 0.004
Hemoglobin (mmol/L) 5.7 (4.8-6.5) 5.8 (5.6-6.1)
Hematocrit 0.29 (0.25-0.30) 0.28 (0.26-0.30)
PTT (sec) 11.8 (10.8-14.5) 11.4 (11.1-12.7) 0.95
aPTT (sec) 32.3 (25.5-36.7) 28.2 (20.3-41.7) 0.57
Antithrombin (%) 79 (43-86) 46 (17-64) 0.23
Platelet count (109/L) 182 (163-286) 139 (96-221) 0.26
Anti-Xa activity (IU) 0.11 (0.00-0.55) 0.01 (0.00-0.15) 0.30
ETPTlag (sec) 23.0 (18.6-31.0) 19.7 (14.3-22.1) 0.13
ETPTmax (sec) 53.1 (46.0-81.4) 52.7 (46.1-54.9) 0.80
ETPCmax (mA/min) 108 (91-125) 114 (75-153) 0.48
ETPAUC (mA) 275 (137-379) 341 (223-401) 0.54
F1+2 (pmol/L) 313 (158-689) 216 (156-288) 0.32
TAT (μg/L) 20.7 (4.8-28.9) 8.3 (6.7-10.5) 0.18
D-dimers (μg/ml) 14.2 (7.6-43.8) 4.1 (1.5-29.8) 0.25
Creatinine (μmol/L) 297 (221-453) 251 (141-329) 0.54
Urea (mmol/L) 34 (15-49) 36 (10-47) 0.81
RIFLE score 3 3 1.0

Values in median (interquartile range) unless indicated differently.

APACHE = Acute Physiology and Chronic Health Evaluation; aPTT = activated thromboplastin time; CVVH = continuous venovenous hemofiltration; ETP = endogenous thrombin potential; ETPAUC = area under the curve of the thrombin generation curve; ETPCmax = maximal activity of ETP; ETPTlag = ETP lag time = ETPTmax = time to max ETP activity; F1+2 = prothrombin fragment; PTT = prothrombin time; SOFA = Sequential Organ Failure Assessment; TAT = thrombin-antithrombin complexes.

RIFLE = Risk = 1, Injury = 2, Failure = 3.