Table 3.
Comparison of baseline markers of coagulation and severity of organ failure between patients with circuit life of 12 hours or less (lower quartile) and those with circuit life more than 12 hours
| Circuit life | ≤12 h n = 4 |
>12 h n = 10 |
P value | ≤12 h n = 4 |
>12 h n = 10 |
P value |
|---|---|---|---|---|---|---|
| Baseline (arterial) | ||||||
| antithrombin (%) | 40 (17-71) | 61 (43-87) | 0.20 | |||
| anti-Xa (IU/ml) | 0.12 (0-0.47) | 0.07 (0-0.17) | 0.94 | |||
| PTT (sec) | 12.6 (12.6-30.5) | 11.4 (10.9-11.6) | 0.004 | |||
| aPTT (sec) | 66 (33-144) | 27 (21-35) | 0.02 | |||
| platelets (109/L) | 159 (86-224) | 173 (115-280) | 0.54 | |||
| ETPTlag (sec) | 27 (15-34) | 20 (19-22) | 0.20 | |||
| ETPTmax (sec) | 47 (26-65) | 54 (50-55) | 0.32 | |||
| ETPCmax | 76 (58-112) | 120 (105-148) | 0.048 | |||
| ETPAUC (mA) | 162 (122-256) | 349 (241-410) | 0.07 | |||
| F1+2 (pmol/L) | 258 (156-651) | 237 (149-388) | 0.74 | |||
| TAT (μg/L) | 23.0 (18.8-34.9) | 7.8 (5.2-13.1) | 0.01 | |||
| D-dimers (μg/ml) | 19.4 (4.1-60.8) | 8.9 (2.3-25.7) | 0.40 | |||
| SOFA start CVVH | 15 (14-15) | 9 (8-11) | 0.02 | |||
| during CVVH and nadroparin infusion (arterial) | during CVVH (postfilter) | |||||
| anti-Xa (IU/ml) | 0.13 (0.04-0.39) | 0.28 (0.21-0.45) | 0.003 | 0.24 (0.16-0.60) | 0.43 (0.32-0.76) | 0.003 |
| PTT (sec) | 13.7 (11.8-30.6) | 11.1 (10.8-11.6) | < 0.001 | 13.2 (11.6-32.4) | 10.5 (10.1-11) | < 0.001 |
| aPTT (sec) | 38.4 (31.9-105.5) | 27.1 (22.9-31.1) | < 0.001 | 37.8 (30.0-63.2) | 25.9 (23.1-29.4) | < 0.001 |
| platelets (109/L) | 135 (114-239) | 154 (119-212) | 0.55 | 162 (118-196) | 198 (159-283) | 0.01 |
| ETPTlag (sec) | 22.9 (17.2-36.2) | 19.2 (15.9-22.4) | 0.03 | 19.8 (17.2-29.4) | 17.4 (12.9-21.5) | 0.02 |
| ETPTmax (sec) | 55.7 (46.8-77.7) | 44.2 (39.8-54.6) | < 0.001 | 51.0 (45.2-55.0) | 38.9 (34.0-44.5) | < 0.001 |
| ETPCmax (mA/min) | 89 (48-109) | 120 (93-143) | < 0.001 | 120 (86-128) | 143 (111-168) | 0.004 |
| ETPAUC (mA) | 173 (128-280) | 258 (167-327) | 0.08 | 173 (122-251) | 213 (29-310) | 0.71 |
| F1+2 (pmol/L) | 192 (148-297) | 288 (176-362) | 0.81 | 313 (187-991) | 382 (254-515) | 0.78 |
| TAT (μg/L) | 27 (18.5-77.1) | 8.2 (6.6-11.4) | < 0.001 | 50.9 (21.6-126) | 8.9 (7.1-15.2) | < 0.000 |
| D-dimers (μg/ml) | 20.2 (12.4-46.4) | 7.8 (2.2-22.4) | 0.002 | 36.4 (15.6-59.4) | 11.0 (3.3-29.7) | 0.002 |
Values in median (interquartile range). Values during CVVH are medians of all samples. Postfilter values are actual values, not corrected for hemoconcentration.
aPTT = activated thromboplastin time; CVVH = continuous venovenous hemofiltration; ETP = endogenous thrombin potential; ETPAUC = area under the curve of the thrombin generation curve; ETPCmax = maximal activity of ETP; ETPTlag = ETP lag time = ETPTmax = time to max ETP activity; F1+2 = prothrombin fragment; PTT = prothrombin time; SOFA = Sequential Organ Failure Assessment; TAT = thrombin-antithrombin complexes.