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. 2009 Dec 9;13(6):R199. doi: 10.1186/cc8203

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Copyright ©2009 Ganzert et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Flow interruption technique. (a) Respiratory flow and (b) pressure P_rstime-series of one 100 mL volume step including the phases of volume loading ( >0 mL/sec) and stress relaxation ( = 0 mL/sec during occlusion interval). (a) Labeled points indicate: (1) start of valve closure, (2) flow falling below zero due to valve characteristics, (3) estimated end of valve closure. The data between (1) and (3) were excluded from the fitting process [see Additional file 1]. (b) P_rswith maximum pressure (P_{rs, max}) and approximated plateau pressure (P_plat). P_{rs, sim}depicts the model-simulated respiratory pressure by use of the fitted parameter values. (i) denotes the initial resistive pressure drop (P_{rs, max}down to P₁), (ii) denotes the succeeding slow pressure change indicating stress relaxation between level P₁and P_plat.

Inline graphic — Flow interruption technique. (a) Respiratory flow and (b) pressure P_rstime-series of one 100 mL volume step including the phases of volume loading ( >0 mL/sec) and stress relaxation ( = 0 mL/sec during occlusion interval). (a) Labeled points indicate: (1) start of valve closure, (2) flow falling below zero due to valve characteristics, (3) estimated end of valve closure. The data between (1) and (3) were excluded from the fitting process [see Additional file 1]. (b) P_rswith maximum pressure (P_{rs, max}) and approximated plateau pressure (P_plat). P_{rs, sim}depicts the model-simulated respiratory pressure by use of the fitted parameter values. (i) denotes the initial resistive pressure drop (P_{rs, max}down to P₁), (ii) denotes the succeeding slow pressure change indicating stress relaxation between level P₁and P_plat.