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. Author manuscript; available in PMC: 2010 Jan 27.
Published in final edited form as: Mutat Res. 2007 Sep 14;638(1-2):103–109. doi: 10.1016/j.mrfmmm.2007.09.003

Table 1.

Effect of celecoxib on DMABP-derived DNA adducts in liver. Values represented are mean ± SEM from 8 animals

Treatment Adducts/109 nucleotides
1 C8-DMABP 3 N2-DMABP 5 6 Total
Control 454 ± 66 3,208 ± 567 2,398 ± 573 3,215 ± 647 239 ± 99 506 ± 138 12,571 ± 1,370
500 ppm celecoxib
% reduction 		374 ± 66
17.6 		1,077 ± 81
66.4 		1,154 ± 133
51.9 		2,008 ± 308
37.5 		149 ± 29
37.6 		399 ± 61
21.1 		7,403 ± 330
41.1
1000 ppm celecoxib
% reduction 		194 ± 77
57.2 		674 ± 118
79.0 		532 ± 80
77.8 		787 ± 70
75.5 		99 ± 13
58.5 		156 ± 40
69.2 		3,873 ± 532
69.2
1500 ppm celecoxib
% reduction
p value 		128 ± 63
71.8
0.0006 		534 ± 136
83.3
< 0.0001 		436 ± 70
81.8
0.0004 		441 ± 78
86.3
< 0.0001 		50 ± 13
79.1
0.0997 		115 ± 24
77.3
0.0053 		2,328 ± 265
81.5
< 0.0001