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. Author manuscript; available in PMC: 2010 Jan 27.
Published in final edited form as: Mutat Res. 2007 Sep 14;638(1-2):103–109. doi: 10.1016/j.mrfmmm.2007.09.003

Table 2.

Effect of celecoxib on DMABP-derived DNA adducts in colon. Values represented are mean ± SEM from 8 animals

Treatment Adducts/109 nucleotides
C8-DMABP 3 N2-DMABP Total
Control 3,062 ± 335 1,489 ± 172 1,171 ± 228 5,723 ± 465
500 ppm celecoxib
% reduction 		1,815 ± 319
40.7 		848 ± 106
43.1 		753 ± 66
35.7 		3,417 ± 343
40.3
1000 ppm celecoxib
% reduction 		914 ± 119
70.1 		341 ± 73
77.1 		392 ± 37
66.5 		1,646 ± 184
71.2
1500 ppm celecoxib
% reduction
p value 		973 ± 202
68.2
<0.0001 		332 ± 90
77.7
<0.0001 		277 ± 27
76.3
0.0002 		1,582 ± 272
72.4
<0.0001