Figure 1.
Schematic representation of homocysteine/folate metabolism. CBS, cystathionine β-synthase; DHF, dihydrofolate; DHFR, dihydrofolate reductase; dTMP, deoxythymidine monophosphate; dUMP deoxyuridine monophosphate; Hcy homocysteine; MTHFD1, methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolaseformyltetrahydrofolate synthetase; MTHFR, 5,10-methylenetetrahydrofolate reductase; MTR, methionine synthase; MTRR, methionine synthase reductase; RFC1, Reduced folate carrier; SAH, S-adenosylhomocysteine; SAM, S-adenosylmethionine; SHMT, Serine hydroxymethyltransferase; THF, tetrahydrofolate; TYMS, thymidylate synthase.