Table 2.
Proportion of the variation (R2) in RBC folate, serum folate and homocysteine concentrations explained by SLC19A1 c.80G>A genotypes in YH3 study participants.
| All | Males | Females | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| R2 (P-value)1 |
Variable Coefficient (SE)2 |
N | R2 (P-value)1 |
Variable Coefficient (SE)2 |
N | R2 (P-value)1 |
Variable Coefficient (SE)2 |
N | ||
| RBC Folate | ||||||||||
| SLC19A1 c.80G>A | 0.02 (0.04) | 363 | 0.01 (0.43) | 192 | 0.05 (0.02) | 169 | ||||
| GA | 0.05 (0.02) | 0.003 (0.03) | 0.09 (0.03) | |||||||
| AA | 0.07 (0.03) | 0.05 (0.04) | 0.10 (0.04) | |||||||
| Serum Folate | ||||||||||
| SLC19A1 c.80G>A | 0.004 (0.54) | 350 | 0.001 (0.95) | 191 | 0.01 (0.32) | 158 | ||||
| GA | 0.02 (0.03) | −0.01 (0.03) | 0.06 (0.04) | |||||||
| AA | 0.04 (0.04) | −0.10 (0.05) | 0.06 (0.05) | |||||||
| Homocysteine | ||||||||||
| SLC19A1 c.80G>A | 0.003 (0.53) | 400 | 0.01 (0.50) | 219 | 0.001 (0.89) | 179 | ||||
| GA | −0.02 (0.02) | −0.03 (0.02) | −0.01 (0.03) | |||||||
| AA | −0.02 (0.02) | −0.03 (0.03) | −0.003 (0.03) | |||||||
1
P-value for test of hypothesis of no linear association between the predictor variable and RBC folate, serum folate or homocysteine.
2
Estimated regression coefficients and standard errors. Variable coefficients estimate the change in RBC folate, serum folate or homocysteine concentration per unit change in the predictor variable.