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. Author manuscript; available in PMC: 2010 Jan 27.
Published in final edited form as: Gastroenterology. 2008 Dec 24;136(4):1339–e2. doi: 10.1053/j.gastro.2008.12.044

Figure 2. Effect of chronic treatment with minocycline (120μg/day, IT) and the p38 inhibitor SB 203580 (4 μg/day, IT) on stress-induced regulation of spinal P-p38, NK1Rs, and IKBα: proteins levels assessed by Western Blot analysis.

Figure 2

P-p38: Greater level of P-p38 is observed in chronic WA compared with sham WA. This effect is blocked by both minocycline and SB 203580. NK1R: Chronic WA-induced increased levels of spinal NK1R is blocked by minocycline, but is not affected by SB203580. IKBα: Chronic WA induces increased level of spinal IKBα. Both minocycline and SB203580 blocked this effect. Treatments had no effect in sham WA. n=4 in each group. Data are Mean ± SEM expressed as % control, * (compared to sham WA + vehicle) or # (compared to WA + vehicle) P<0.05, One way ANOVA followed by Bonferroni post-test.