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. Author manuscript; available in PMC: 2010 Jan 27.
Published in final edited form as: Gastroenterology. 2008 Dec 24;136(4):1339–e2. doi: 10.1053/j.gastro.2008.12.044

Figure 4. Effect of chronic treatment with the p38 inhibitor SB203580 (4 μg/day/IT) on stress-induced visceral hyperalgesia.

Figure 4

Stressed rats treated with vehicle showed increased EMG response to CRD compared with baseline (n=4) (top panel) whereas rats treated with SB203580 showed no increase of the EMG response at day 11 (n=6) (middle panel). *P<0.05 significantly different from baseline. The bottom panel illustrates the significant difference between the effect of SB203580 and vehicle with *P<0.05 significantly different from vehicle. Data are Mean ± SEM. Two way ANOVA followed by Bonferroni post-test.