Figure 5.

FKBP12.6^−/− mice develop obesity after an HF diet. A) Representative male FKBP12.6^−/− mice and control littermates fed an HF diet for 5 mo. B, C) Body weight of FKBP12.6^−/− mice (B) and WT control mice (C) fed control or HF diets. WT and FKBP12.6^−/− mice fed control or HF diets were weighed 1×/mo during the course of the experiment. Diets were started when mice were 1 mo old. Data are means ± se from mo 1, 4, and 8 for WT [control, n=10; HF diet (HFD), n=10] and KO (control, n=10; HFD, n=8). *P < 0.05; **P < 0.01.