Figure 2.

Regulation of genes encoding proteins predicted to be involved in PDIMs, mycolic acids, PPE-family, ESAT-6/CFP-10, carbon, and intermediary metabolism. Yellow-blue display summarizes the regulation of selected Opp-modulated genes, comparing WT vs. mutant (opp KO) expression. cDNA ratios of statistically significantly affected genes were averaged, log₂ transformed, and displayed according to the color code at the top of the display. Black fields indicate genes with no significant change at a particular growth phase. Experimental conditions were as indicated in Materials and Methods. Genes were selected based on a demonstrated or presumed function of the encoded proteins and grouped in the following categories: virulence-associated lipids (A) and proteins (B) or involved in carbon (C) or intermediary metabolism (D).