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Clarithromycin AUC∞ and relative bioavailability after single doses of clarithromycin. Top, predicted (
) and observed (■) clarithromycin AUC∞ after single doses of clarithromycin. Error bars represent S.E. in 100 simulated subjects (predicted) or in observed subjects (n = 6 for 100 mg of clarithromycin; n = 8 for all other doses) (Chu et al., 1992). Bottom, relative bioavailability of clarithromycin compared with 100 mg oral dosage. ●, observed data; △, predicted values.
