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Effect of altering kinact, KI, and kdeg on inactivation of CYP3A during a 7-day course of 500 mg of clarithromycin orally every 12 h. Top, intestinal/hepatic kinact values were 2/0.2 (·····), 4/0.4 (——), and 8/0.8 (– – –). Middle, KI values were 10 (·····), 4 (——), and 1 (– – –). Bottom, CYP3A half-life was 20 h (·····), 28 h (——), and 40 h (– – –).
