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Dose-response curves for transactivation of LXRα and suppression of RORα and RORγ by T0901317. 293T cells were cotransfected with UAS-luciferase and Gal4-LXRα (A) or Gal4-RORα/γ (B) and were treated with various concentration of T0901317 for 20 h followed by luciferase activity measurement. Relative change was determined by normalizing to control vector treated with vehicle. Each data point was performed in eight replicates and is represented as the mean ± S.E.M., n = 8.
