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Immunization protocols for FI-BRSV coadjuvanted with CpG ODN and PP
| Groupa | 1st immunization (day 0) | 2nd immunization (day 21) | Challenge (day 35) |
|---|---|---|---|
| FI-BRSV (i.n./i.n.) | Intranasal | Intranasal | BRSV |
| FI-BRSV (i.n./s.c.) | Intranasal | Subcutaneous | BRSV |
| FI-BRSV (s.c./i.n.) | Subcutaneous | Intranasal | BRSV |
| FI-BRSV (s.c./s.c.) | Subcutaneous | Subcutaneous | BRSV |
| Saline-BRSV challenge | Intranasal | Intranasal | BRSV |
| Saline-saline | Intranasal | Intranasal | Saline |
FI-BRSV was formulated with 4 μg CpG ODN and 25 μg PP.
