TABLE 1.
M. tuberculosis proteins tested for MHC class II peptide binding
| Protein name | Gene name | Functional classification |
|---|---|---|
| 10-kDa chaperonin GROES CAB01005 | Rv3418c | Virulence, detoxification, adaptation |
| 60-kDa chaperonin 2 P0A521 | Rv0440 | Virulence, detoxification, adaptation |
| Heat shock protein HSP CAA17343 | Rv0251c | Virulence, detoxification, adaptation |
| Heat shock protein HSPX CAA17245 | Rv2031c | Virulence, detoxification, adaptation |
| MCE family protein MCE1A YP_177701 | Rv0169 | Virulence, detoxification, adaptation |
| Possible hemolysin CAA16235 | Rv3922c | Virulence, detoxification, adaptation |
| Possible hemolysin-like protein CAA17201 | Rv1085c | Virulence, detoxification, adaptation |
| 3-Oxoacyl-[acyl-carrier protein] synthase 2 KASB CAA94642 | Rv2246 | Lipid metabolism |
| Biotinylated protein TB7.3 CAB08316 | Rv3221c | Lipid metabolism |
| M. Bovis acyl- coenzyme A synthase gene; U75685 | Lipid metabolism | |
| M. Bovis mycocerosic acid synthase gene M95808 | Lipid metabolism | |
| Putative cyclopropane-fatty-acyl-phospholipid synthase UFAA1 NP_854118 | Rv0447c | Lipid metabolism |
| Secreted antigen 85-B FBPB (85B) CAB10044 | Rv1886c | Lipid metabolism |
| Alternate RNA polymerase sigma factor SIGF CAB07069 | Rv3286c | Information pathways |
| Probable 50S ribosomal protein L7/L12 RPLL CAB07109 | Rv0652 | Information pathways |
| RNA polymerase beta subunit AAA21416 | Rv0667 | Information pathways |
| RNA polymerase beta′ subunit AAA21417 | Rv0667 | Information pathways |
| 10-kDa culture filtrate antigen ESXB | Rv3874 | Cell wall and cell processes |
| Immunogenic protein MPT63 CAB06500 | Rv1926c | Cell wall and cell processes |
| Cell surface lipoprotein MPT83 CAB08316 | Rv2873 | Cell wall and cell processes |
| Conserved hypothetical protein TB9.8 CAD93159 | Rv0287 | Cell wall and cell processes |
| ESAT-6-like protein ESXQ CAA16102 | Rv3017c | Cell wall and cell processes |
| Immunogenic protein MPT64 CAA98382 | Rv1980c | Cell wall and cell processes |
| Lipoprotein LPQH precursor P0A5J0 | Rv3763 | Cell wall and cell processes |
| Low-molecular-weight protein antigen 7 ESXH TB10.4 CAA17363 | Rv0288 | Cell wall and cell processes |
| Low-molecular-weight T-cell antigen TB8.4NP_215690 | Rv1174c | Cell wall and cell processes |
| Major secreted immunogenic protein CAA98373 | Rv2875 | Cell wall and cell processes |
| Periplasmic phosphate-binding lipoprotein PSTS1 YP_177770 | Rv0934 | Cell wall and cell processes |
| Periplasmic phosphate-binding lipoprotein PSTS2 YP_177769 | Rv0932c | Cell wall and cell processes |
| Periplasmic phosphate-binding lipoprotein PSTS3 YP_177768 | Rv0928 | Cell wall and cell processes |
| Probable cutinase precursor CFP21 NP_216500 | Rv1984c | Cell wall and cell processes |
| Probable lipoprotein LPRJ CAB10947 | Rv1690 | Cell wall and cell processes |
| Putative ESAT-6-like protein ESXN YP_177838 | Rv1793 | Cell wall and cell processes |
| Secreted ESAT-6-like protein ESXR CAA16104 | Rv3019c | Cell wall and cell processes |
| 6-kDa early secretory antigenic target ESXA(ESAT-6) CAE55648 | Rv3875 | Cell wall and cell processes |
| PE family protein CAE55335 | Rv0916c | PE/PPE |
| PPE family protein CAE55371 | Rv1196 | PE/PPE |
| PPE family protein YP 177963 | Rv3347c | PE/PPE |
| PPE family protein CAE55334 | Rv0915c | PE/PPE |
| PPE family protein CAE55489 | Rv2430c | PE/PPE |
| PPE family protein CAE55504 | Rv2608 | PE/PPE |
| Secreted l-alanine dehydrogenase ALD CAA15575 | Rv2780 | Intermediary metabolism and respiration |
| Possible glycosyltransferase CAB05418 | Rv2958c | Intermediary metabolism and respiration |
| Possible glycosyltransferase CAB05419 | Rv2957 | Intermediary metabolism and respiration |
| Probable isocitrate dehydrogenase CAA17111 | Rv3339c | Intermediary metabolism and respiration |
| Probable isocitrate dehydrogenase CAA16247 | Rv0066c | Intermediary metabolism and respiration |
| Probable molybdopterin-guanine dinucleotide biosynthesis protein CAA16030 | Rv2453c | Intermediary metabolism and respiration |
| Probable serine protease PEPA CAB09453 | Rv0125 | Intermediary metabolism and respiration |
| Probable serine protease PEPD CAA17582 | Rv0983 | Intermediary metabolism and respiration |
| Possible glycosyltransferase CAB05415 | Rv2962c | Intermediary metabolism and respiration |
| MTB48 AAK31576 | Unknown | |
| MTB81 | Unknown | |
| Transmembrane serine/threonine-protein kinasE D PKND NP_215446 | Rv0931c | Regulatory proteins |
| Two-component transcriptional-regulatory protein DEVR NP_217649 | Rv3133c | Regulatory proteins |
| Conserved hypothetical protein CFP17 CAB01474 | Rv1827 | Conserved hypotheticals |
| Conserved hypothetical protein TB16.3CAD97060 | Rv2185c | Conserved hypotheticals |
| Conserved hypothetical protein TB18.5CAD93033 | Rv0164 | Conserved hypotheticals |
| Hypothetical protein NP_217139 | Rv2623 | Conserved hypotheticals |
| Hypothetical protein NP_217142 | Rv2626c | Conserved hypotheticals |
| Iron-regulated conserved hypothetical protein CAB08889 | Rv1636 | Conserved hypotheticals |
| Conserved hypothetical protein CAB08634 | Rv2629 | Conserved hypotheticals |