Fig. 4.

Effects of presession treatments with σR antagonists on self-administration of DTG in rats trained to self-administer cocaine. Ordinates, responses per second. Abscissae, injection dose in mg/kg. Each point represents the mean ± S.E.M. (n = 6). BD 1008, BD 1047, and BD 1063 were administered intraperitoneally at 5, 15, and 5 min before sessions, respectively. A, effects of BD 1008 (1.0, 3.2, and 10 mg/kg) on DTG self-administration. B, effects of BD 1047 (1.0, 3.2, and 10 mg/kg) on DTG self-administration. C, effects of BD 1063 (1.0, 3.2, and 10 mg/kg) on DTG self-administration.