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Effects of presession treatments with WIN 35,428 on self-administration of σR agonists in rats trained to self-administer cocaine. Ordinates, responses per second. Abscissae, injection dose in mg/kg. Each point represents the mean ± S.E.M. (n = 6). WIN 35,428 was administered intraperitoneally at 5 min before sessions. A, effects of WIN 35,428 (0.1, 0.32, and 1.0 mg/kg) on DTG self-administration. B, effects of WIN 35,428 (0.1, 0.32, and 1.0 mg/kg) on PRE-084 self-administration.
