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. 2010 Feb;332(2):515–524. doi: 10.1124/jpet.109.159236

Table 1.

ED50 values (in milligrams per kilogram with 95% confidence limits) for σR antagonists and agonists in decreasing rates of responding maintained by DTG, PRE-084, cocaine, or food presentation

Treatment DTG PRE-084 Cocaine Food Presentation
BD 1008 2.88 (2.46–3.36) 2.19 (1.35–3.13) NS 13.2 (7.02–35.6)
BD 1047 9.47 (5.96–14.6) NT ND 14.3 (7.46–46.2)
BD 1063 2.95 (2.46–3.52) NT NS 15.0 (5.23–3590)

NS, nonsignificant linear regression; ND, not determined; NT, not tested.