PHE-induced contraction in pulmonary and mesenteric artery segments of normoxic, hypoxic, and MCT-treated rats. Pulmonary artery (A and C) and mesenteric artery rings (B and D) were stimulated with increasing concentrations of PHE. The contractile response was measured and presented in grams per milligram tissue weight for pulmonary vessels (A), in grams for mesenteric vessels (B), or as percentage of maximal PHE contraction (C and D). Data represent means ± S.E.M. (n = 6–16). *, measurements in hypoxic and MCT-treated rats are significantly different (p < 0.05) from corresponding measurements in normoxic rats.