Fig. 7.

Pulmonary vascular remodeling in hypoxic and MCT-treated models of PH. A, representative hematoxylin and eosin-stained peripheral lung sections from control normoxic rat, and hypoxic (2 weeks) and MCT-treated rats. Pulmonary arterioles are indicated with arrows. Total magnification, 400×. Scale bar = 50 μm. B, quantitative morphometric analysis of percentage of wall thickness of pulmonary arterioles defined as the area occupied by the vessel wall divided by the total cross-sectional area of the arteriole. Graph bars represent the means ± S.E.M. of measurements in 15 vessels per rat, five rats from each experimental group. *, p < 0.001 compared with the normoxic group.