Fig. 3.

Ro4-1284 and TBZ inhibition of [³H]DTBZ binding assays conducted in rat whole brain versus striatal preparations. The affinity of two standards (Ro4-1284, top; TBZ, bottom) for the [³H]DTBZ binding site located on VMAT2 were analyzed in both rat whole brain and striatal preparations. Control indicates the absence of the standard. Data indicate mean ± S.E.M. and are presented as a percentage of their respective controls (whole brain, 1225 ± 81.1 fmol/mg; striatum, 448.8 ± 20.2 fmol/mg; n = 3 rats/standard, per preparation).