TABLE 1.

Organism titers in vegetations, spleens, and kidneys of untreated and antibiotic-treated rabbits infected with MRSA COL strain

Treatment (no. of rabbits)	Mean organism titer (log10 CFU/g ± SD) (no. sterile)			Comparison between ceftobiprole and other groups (P)			Comparison between control and other groups (P)
	Vegetation	Spleen	Kidneys	Vegetation	Spleen	Kidneys	Vegetation	Spleen	Kidneys
Ceftobiprole (7)	2.1 ± 1.0 (6)	1.8 ± 0.2 (5)	1.7 ± 0 (7)				<0.001	<0.001	<0.001
Control (6)	8.4 ± 0.7 (0)	5.1 ± 0.9 (0)	4.4 ± 1.0 (0)	<0.001	<0.001	<0.001
Daptomycin (7)	3.6 ± 1.4 (1)	2.3 ± 0.7 (2)	2.6 ± 1.1 (3)	0.030	0.080	0.055	<0.001	<0.001	0.011
Vancomycin (6)	5.9 ± 2.8 (1)	3.3 ± 1.6 (2)	3.1 ± 1.5 (3)	0.006	0.025	0.036	0.050	0.035	0.102
Linezolid (5)	5.9 ± 1.2 (0)	2.9 ± 0.4 (0)	2.5 ± 0.6 (1)	<0.001	0.001	0.005	0.001	<0.001	0.007