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In situ formation of topoisomerase-DNA cleavable complexes
| Compounda (μM) | Cleavable complexes |
|
|---|---|---|
| % of total DNAb | Ratio to DMSO | |
| DMSO | 2.2 ± 0.05 | 1.0 |
| Etoposide (500) | 9.0 ± 0.81 | 4.2 |
| 1895 (50) | 1.9 ± 0.09 | 0.86 |
| 0020 (50) | 1.7 ± 0.13 | 0.79 |
Each compound was assayed in triplicate.
KSDS-precipitable radioactivity in treated cells, as a percentage of trichloroacetic acid-precipitable radioactivity in untreated cells. Values are means ± standard deviations.
