TABLE 4.

Neuropsychiatric events in subjects on tafeoquine or mefloquine (prophylactic phase)^a

Adverse event	No. (%) of subjects by AE severity and treatment group
	Mild		Moderate		Total
	Tafenoquine	Mefloquine	Tafenoquine	Mefloquine	Tafenoquine	Mefloquine
Vertigo	22 (5)	7 (4)	0	1 (<1)	22 (5)	8 (5)
Somnolence	12 (2)	6 (4)	0	0	12 (2)	6 (4)
Abnormal dreams	7 (1)	2 (1)	0	0	7 (1)	2 (1)
Dizziness	5 (1)	2 (1)	0	0	5 (1)	2 (1)
Insomnia	4 (<1)	3 (2)	1 (<1)	0	5 (1)	3 (2)
Abnormal coordination	2 (<1)	1 (<1)	0	0	2 (<1)	1 (<1)
Anxiety	2 (<1)	0	0	0	2 (<1)	0
Agitation	2 (<1)	0	0	0	2 (<1)	0
Euphoria	2 (<1)	0	0	0	2 (<1)	0
Tremor	2 (<1)	0	0	0	2 (<1)	0
Depression	0	0	1 (<1)	1 (<1)	1 (<1)	1 (<1)
Paroniria	1 (<1)	0	0	0	1 (<1)	0
Amnesia	1 (<1)	0	0	0	1 (<1)	0

^aIn total, there were 492 tafenoquine subjects and 162 mefloquine subjects. There were no severe adverse events (AEs) of this type.