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BIT225, a novel inhibitor of HIV-1 Vpu ion channels. Here we show the chemical structure of BIT225 (a), a novel compound that inhibits the Vpu ion channel when used in a phospholipid bilayer assay (b). The traces in panel b are continuous 16-s data sets representative of ion currents detected at a holding potential of −40 mV before and after addition of BIT225 (40 mM final concentration) to the cis and trans chambers.
