FIG. 2.

Mean EC₅₀ and TC₅₀ dose-response curves for BIT225 treatment of HIV-1_Ba-L-infected MDM. Shown are the mean dose-response curves for MDM, with bars representing standard errors of the means, indicating the effects of BIT225 on HIV-1_Ba-L replication in human MDM (a) and the effects of BIT225 on day 14 MDM viability (b). The mean EC₅₀ of BIT225 ± SE was 2.25 ± 0.23 μM (n, 6 separate experiments with each drug concentration assayed in triplicate), and the mean TC₅₀ was 284 ± 22 μM (n = 3), resulting in a selectivity index of 126.