FIG. 4.

The anti-HIV-1 effects of BIT225 are exerted late in the viral life cycle. Compared to the control drugs in each of the assays, BIT225 at 10 μM does not interfere with viral integration, as demonstrated by a lack of activity with the indicator cell line TZM-bl (a), does not interfere with the process of reverse transcription or with the viral RT enzyme (b), and does not affect the viral protease enzyme (c). Shown are data representative of results from three separate experiments. Concentrations of BIT225 are expressed as micromolar concentrations and those of EFV, LPV, and SQV are expressed as nanomolar concentrations.