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Fourteen-day survival as a function of the posaconazole dose/MIC ratio for 4 A. fumigatus isolates. Shown are data for the wild type (WT) (MIC, 0.031 mg/liter) and for the TR L98H (MIC, 0.5 mg/liter), M220I (MIC, 0.5 mg/liter), and G54W (MIC, >16 mg/liter) mutants. The curve is the model fit with the Hill equation for pooled data.
