TABLE 2.
Pharmacokinetic parameters of posaconazole after doses of 1 to 64 mg/kg administered by oral gavage
| Posaconazole dose (mg/kg) | Value for the following pharmacokinetic parameter (unit)a: |
||||||
|---|---|---|---|---|---|---|---|
| AUC (h·mg/liter) | Dose-normalized AUC [h/(liter·kg)] | CLss/F [liters/(h·kg)] | C24 (mg/liter) | Cavg (mg/liter) | Cmax (mg/liter) | Tmax (h) | |
| 1 | 10.20 | 10.19 | 0.10 | 0.11 (0.05) | 0.42 | 0.98 (0.21) | 4.00 |
| 4 | 45.07 | 11.27 | 0.09 | 0.94 (0.39) | 1.88 | 3.11 (0.68) | 2.00 |
| 16 | 159.42 | 9.96 | 0.10 | 2.70 (0.57) | 6.64 | 9.03 (1.75) | 8.00 |
| 64 | 296.72 | 4.64 | 0.22 | 9.33 (2.77) | 12.36 | 17.83 (4.60) | 8.00 |
a
For Cmax and the concentration at 24 h (C24), values in parentheses are standard deviations (n = 3).