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Representative liver immunohistochemistry for HBcAg expression in bortezomib-treated mice. (A) A control section of human liver from an HBV-positive patient revealed numerous HBV-positive hepatocytes with strong cytoplasmic and nuclear staining (arrowheads). (B and C) There was no significant difference in the number and distribution of HBV-positive hepatocytes (arrowheads) in HBV-infected mice 1 day after intravenous injection of saline (B) or 1 mg/kg bortezomib (C). Bars, 100 μm.
