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. 2009 Nov 30;54(2):749–756. doi: 10.1128/AAC.01101-09

FIG. 6.

FIG. 6.

Bortezomib does not induce an IFN response in the liver. (A and C) Intrahepatic expression of the representative IFN-inducible genes ISG15, Usp18, and TGTP was measured by quantitative real-time RT-PCR (qRT-PCR) in mice either 1, 2, 3, or 6 days after intravenous injection of 1 mg/kg bortezomib (A) or 24 h after a single dose of 0.2, 1.0, or 5.0 mg/kg bortezomib (C). Results for each individual mouse are shown. Results are displayed as fold changes compared to one control mouse and are normalized to GAPDH expression. (B) RNase protection assay (RPA) of cytokine mRNA expression in the livers of individual mice 1, 2, 3, and 6 days after intravenous injection of 1 mg/kg bortezomib.