TABLE 2.
Activity of WLBU2 and 3-OG in combination against C. trachomatis serovar L2 inclusion formation after 5 min of exposurea
| WLBU2 concn (μM) | Activity (%) at 3-OG concn (mM) ofb: |
|||||||
|---|---|---|---|---|---|---|---|---|
| 7.5 | 3.75 | 1.88 | 0.94 | 0.47 | 0.23 | 0.12 | 0.00 | |
| 60 | 100.000 | †100.000 | ‡99.995 | ‡98.658 | †97.672 | ‡94.983 | 94.082 | 92.486 |
| 100.000 | 96.303 | 92.222 | 91.932 | 92.742 | 92.502 | 92.348 | ||
| 30 | 100.000 | †100.000 | †99.934 | †98.080 | †97.410 | 95.679 | 94.440 | 91.048 |
| 100.000 | 94.708 | 89.472 | 89.013 | 92.911 | 92.404 | 92.408 | ||
| 15 | 100.000 | †100.000 | †99.695 | †95.652 | †96.028 | 93.222 | 91.057 | 87.300 |
| 100.000 | 91.601 | 83.724 | 83.200 | 91.348 | 90.879 | 90.817 | ||
| 7.5 | 100.000 | †100.000 | †99.260 | †93.674 | ‡92.414 | 89.042 | 86.281 | 79.663 |
| 100.000 | 87.573 | 75.375 | 74.524 | 84.473 | 83.700 | 83.549 | ||
| 3.75 | 100.000 | 100.000 | 96.985 | 85.390 | 81.966 | 78.976 | 75.924 | 69.552 |
| 100.000 | 84.874 | 69.132 | 66.651 | 70.954 | 69.606 | 69.322 | ||
| 1.88 | 100.000 | †99.952 | †93.778 | †80.721 | 71.437 | 67.217 | 58.116 | 49.782 |
| 100.000 | 68.898 | 47.623 | 48.006 | 40.026 | 36.334 | 39.646 | ||
| 0.00 | 100.000 | 43.229 | -1.387 | -1.465 | -1.637 | -6.235 | -5.050 | 0.000 |
The data are presented as the average actual activity (percent inhibition) of the combinations. Directly underneath stated activity is the average expected percent inhibition of the combinations if the activity was additive. SDs are not reported in this table, but the “†” symbol indicate the actual activity is significantly different from the expected activity at the alpha = 0.05 level (two-sided paired t test). The “‡” symbol indicates the actual activity is significantly different from the expected activity at the alpha = 0.1 level (two-sided paired t test). The activities of the compounds singly are represented in boldface in the bottom row (3-OG) and the last column (WLBU2).
Activity reported for each compound alone at each of various concentrations (bottom row and last column) is the average of results from all experiments performed with that concentration. For technical reasons, some concentrations of each compound were tested in more than three experiments. The expected activity for each concentration combination that is reported within the table was calculated based on the activity of each compound alone in the same experiments.