. 2009 Oct 5;54(2):583–589. doi: 10.1128/AAC.01095-09

TABLE 1.

23S rRNA gene mutations associated with spirochete macrolide resistance

Spirochete	Mutation position^a	Resistance(s)^b	Clinical/induced^c	Reference^d
T. pallidum	A2058G	Ery, Azi	Clinical	71
	A2059G	Spi	Clinical	44
T. denticola	A2058G	Ery	Induced	35
B. hyodysenteriae	A2058G	Ery, Cli, Tyl	Induced	28
	A2058T	Ery, Cli, Tyl	Clinical	28
B. pilosicoli	A2058G	Tyl	Induced	56
	A2058T	Ery, Cli, Tyl	Clinical	29
	A2059C	Ery, Cli, Tyl	Clinical	29
	A2059G	Ery, Cli, Tyl	Clinical	29
Brachyspira spp.	A2062C	Tyl	Induced	56

Based on the numbering of the E. coli 23S rRNA gene nucleotide sequence.

Based on the antibiotics tested. Azi, azithromycin; Cli, clindamycin; Ery, erythromycin; Spi, spiramycin; Tyl, tylosin.

Macrolide resistance present in clinical/field isolate versus experimentally induced resistance.

Initial description of mutation.