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KPC-2 inhibitor kinetics with the β-lactamase inhibitorsa
| Drug | Km (μM) | kinact (s−1) | kinact/Km ratio (μM−1 s−1) | tn (kcat/kinact) |
|---|---|---|---|---|
| Clavulanate | 8.4 ± 0.8 | 0.027 ± 0.001 | 0.0036 ± 0.0004 | ∼2,500 |
| Sulbactam | 135 ± 1 | 0.16 ± 0.01 | 0.0012 ± 0.0001 | ∼1,000 |
| Tazobactam | 78.5 ± 7.9 | 0.20 ± 0.01 | 0.0025 ± 0.0002 | ∼500 |
| Penem 1 | 0.06 ± 0.01 | 0.011 ± 0.001 | 0.18 ± 0.02 | ∼250 |
| Penem 2 | 0.006 ± 0.001 | 0.039 ± 0.002 | 6.5 ± 0.6 | ∼25 |
Values are means ± standard deviations.
