TABLE 1.

Drug levels in serum and brain tissue measured by bioassay on day 6 of therapy and 4 h after last dosing

Drug	Mean ± SD drug level in:
	Serum (μg/ml)	Brain (μg/g)
PSC
10 mg/kg	5.17 ± 0.99	2.02 ± 0.19
20 mg/kg	6.35 ± 0.97	2.84 ± 0.74
40 mg/kg	9.72 ± 0.57	6.73 ± 0.88
ITZ (50 mg/kg)	7.32 ± 3.44	6.88 ± 1.52
AMB (1.5 mg/kg)	6.45 ± 0.54	5.71 ± 0.43