FIG. 6.

(A) PyMSP1₁₉-specific inhibitory activity in sera from mice immunized with recombinant PyMSP1₁₉ (circles) or PBS control (triangles). Each serum was tested in triplicate at a final concentration of 10% on two transgenic lines, D10-PfM3′ and D10-PyMEGF, which express either the endogenous MSP1₁₉ or the homologous region from P. yoelii. PyMSP1₁₉-specific inhibition was calculated by subtracting the invasion rate of D10-PyMEGF from that of D10-PfM3′. The horizontal lines indicate the means of the values. (B) Lack of correlation between invasion-inhibitory activity (as a percentage) and antibody level, measured by ELISA (OD at 1:10,000 dilution).