TABLE 2.
Malaria-related clinical outcomes during the 9-month study period, by age group
| Outcome | Value for age group |
Value for all individuals (n = 225) | P valuea | |||
|---|---|---|---|---|---|---|
| 2-4 yr (n = 73) | 5-7 yr (n = 52) | 8-10 yr (n = 51) | 18-25 yr (n = 49) | |||
| Malaria incidence (mean ± SD)b | 1.99 ± 1.25 | 1.94 ± 1.21 | 0.98 ± 1.05 | 0.08 ± 0.28 | 1.33 ± 1.30 | <0.001 |
| No. of cases of severe malariac | 4 | 1 | 0 | 0 | 5 | |
| Time to first malaria episode for those who experienced malaria (days [median])d | 101 | 114 | 130 | 153 | 115 | 0.02 |
| No. (%) of individuals with at least one malaria episode | 63 (86.3) | 45 (86.5) | 31 (60.8) | 4 (8.2) | 143 (63.6) | <0.001 |
| Level of parasitemia at first malaria episode (no. of parasites/μl) (geometric mean [95% CI]) | 34,374 (24,955-47,348) | 15,687 (9,623-25,574) | 10,433 (5,079-21,427) | 8,816 (4,082-19,037) | 19,625 (15,004-25,668) | 0.04 |
a
P values were derived by using Fisher's exact test for categorical variables and the Kruskal-Wallis test for continuous variables.
b
A malaria episode was defined as a temperature of >37.5°C, asexual parasitemia of >5,000 parasites/microliter, and nonfocal physical examination.
c
According to WHO definition of severe malaria.
d
Days since study enrollment.