FIG. 4.

Lack of Bim does not relieve the block in T-cell development caused by the absence of IL-7. Bone marrow from Bim^−/− or WT mice was used to reconstitute irradiated Rag2^−/− or IL-7^−/− Rag2^−/− recipients. Eight weeks later, thymuses were harvested from recipients. (A) Thymic cellularity for individual recipients. Means ± standard deviations for 2 to 3 mice from two independent experiments are shown (*, P = 0.009; *, P = 0.001). (B) Thymocytes were stained for CD4 and CD8 (top) or TCRαβ and TCRδγ (bottom). Cell percentages for each quadrant are shown in the upper right corner. Values represent data for five mice from two individual experiments.