TABLE 1.

Fluconazole and voriconazole MIC₅₀s and MIC₉₀s obtained with VK2, CLSI (24 h and 48 h), and Etest (24 h and 48 h)

Candida sp. (no. of isolates), azole, and method	24 h			48 h			EAa (%)
	MIC range	MIC50	MIC90	MIC range	MIC50	MIC90
C. albicans (84)
Fluconazole
VK2	≤1-≥64d	≤1	≤1
CLSI	<0.125-64	0.125	0.5	<0.125->64	0.5	2	98.8
Etest	0.094-128	0.25	0.38	0.094->256	0.625	2	89.3
Voriconazole
VK2	≤0.12-0.5	≤0.12	≤0.12
CLSI	<0.03-1	0.03	0.125	<0.03-2	0.03	0.125	100
Etest	0.003-1	0.008	0.023	0.002-2	0.02	0.064	98.8
C. parapsilosis (22)
Fluconazole
VK2	≤1	≤1	≤1
CLSI	<0.125-8	0.125	0.5	<0.125-8	0.25	0.5	95.4
Etest	0.064-0.5	0.315	0.38	0.064-8	1	1.5	90.9
Voriconazole
VK2	≤0.12	≤0.12	≤0.12
CLSI	<0.03-0.25	<0.03	<0.03	<0.03-0.25	<0.03	0.03	100
Etest	0.004-0.047	0.012	0.023	0.006-0.19	0.032	0.064	100
C. tropicalis (17)
Fluconazole
VK2	≤1-2	≤1	2
CLSI	<0.125-2	0.25	0.5	0.125-2	0.5	2	100
Etest	0.5-2	1.5	1.5	0.38-6	1.5	3	64.7
Voriconazole
VK2	≤0.12	≤0.12	≤0.12
CLSI	<0.03-0.06	0.03	0.06	0.03-0.25	0.06	0.125	100
Etest	0.016-0.094	0.047	0.094	0.012-0.25	0.094	0.19	100
Other Candida spp. (5)c
Fluconazole
VK2	≤1-2	≤1	≤1
CLSI	<0.125-0.5	0.125	0.125	<0.125-4	0.125	0.125	100
Etest	0.064-3	0.75	0.75	0.064-3	0.75	0.75	100
Voriconazole
VK2	≤0.12-≤0.12	≤0.12	≤0.12
CLSI	<0.03-<0.03	<0.03	<0.03	<0.03-<0.03	<0.003	<0.003	100
Etest	0.004-0.094	0.023	0.023	0.004-0.094	0.023	0.023	100
C. glabrata (56)
Fluconazole
VK2	≤1-≥64	8	32
CLSI	<0.125-64	2	8	0.125->64	6	16	94.6
Etest	0.094->256	7	16	0.094->256	>256	>256	25
Voriconazole
VK2	≤0.12-≥8	≤0.12	2
CLSI	<0.03-8	0.125	0.5	0.03-8	0.125	2	89.3
Etest	0.016-8	0.125	1.5	0.032->32	1.5	32	32.1
C. inconspicua (5), C. norvegensis (2)
Fluconazole
VK2	4-≥64	16	16
CLSI	<0.125-16	<0.125	<0.125	2-32	16	16	100
Etest	8-24	10	10	24->256	>256	>256	85.7
Voriconazole
VK2	≤0.12-0.25	≤0.12	≤0.12
CLSI	<0.03-0.5	<0.03	<0.03	0.03-0.5	0.25	0.25	100
Etest	0.19-2	0.19	0.19	0.19-2	0.19	0.19	85.7
C. krusei (14)
Fluconazole
VK2	4-32	16	32				100/92.8b
CLSI	0.25-64	16	32	8-64	32	64	100b
Etest				32->256	>256	>256
Voriconazole
VK2	≤0.12-0.25	≤0.12	0.25
CLSI	0.03-0.5	0.25	0.5	0.25-1	0.5	1	92.8
Etest	0.19-0.5	0.25	0.25	0.064-1.5	0.25	1.5	64.3

^aEA between VK2 and the two other methods at 48 h.

^bEA calculated with Vitek 2 expert software interpretive values.

^cC. lusitaniae (n = 2), C. guilliermondii (n = 1), C. kefyr (n = 1), and C. dubliniensis (n = 1).

^dMICs are in micrograms per milliliter.