TABLE 2.
ECVs for anidulafungin, caspofungin, and micafungin and eight species of Candida
| Species | Antifungal agent | No. of isolates tested | MIC (μg/ml) |
% Isolates with MIC of ≤2 μg/ml | ||
|---|---|---|---|---|---|---|
| Range | Mode | ECV (%a) | ||||
| C. albicans | Anidulafungin | 4,283 | 0.007-1 | 0.03 | 0.12 (99.7) | 100.0 |
| Caspofungin | 4,283 | 0.007-0.5 | 0.03 | 0.12 (99.8) | 100.0 | |
| Micafungin | 4,283 | 0.007-0.5 | 0.015 | 0.03 (97.7) | 100.0 | |
| C. glabrata | Anidulafungin | 1,236 | 0.015-4 | 0.06 | 0.25 (99.4) | 99.9 |
| Caspofungin | 1,236 | 0.015-8 | 0.03 | 0.12 (98.5) | 99.8 | |
| Micafungin | 1,236 | 0.007-2 | 0.015 | 0.03 (98.2) | 100.0 | |
| C. tropicalis | Anidulafungin | 996 | 0.007-2 | 0.03 | 0.12 (98.9) | 100.0 |
| Caspofungin | 996 | 0.007->8 | 0.03 | 0.12 (99.4) | 99.9 | |
| Micafungin | 996 | 0.007-1 | 0.015 | 0.12 (99.1) | 100.0 | |
| C. kefyr | Anidulafungin | 61 | 0.015-0.12 | 0.06 | 0.25 (100.0) | 100.0 |
| Caspofungin | 61 | 0.007-0.03 | 0.015 | 0.03 (100.0) | 100.0 | |
| Micafungin | 61 | 0.015-0.06 | 0.06 | 0.12 (100.0) | 100.0 | |
| C. krusei | Anidulafungin | 270 | 0.015-0.5 | 0.03 | 0.12 (99.3) | 100.0 |
| Caspofungin | 270 | 0.015-1 | 0.06 | 0.25 (96.3) | 100.0 | |
| Micafungin | 270 | 0.015-0.25 | 0.06 | 0.12 (97.8) | 100.0 | |
| C. lusitaniae | Anidulafungin | 99 | 0.06-1 | 0.5 | 2 (100) | 100.0 |
| Caspofungin | 99 | 0.03-1 | 0.25 | 0.5 (98.0) | 100.0 | |
| Micafungin | 99 | 0.007-1 | 0.12 | 0.5 (99.0) | 100.0 | |
| C. parapsilosis | Anidulafungin | 1,238 | 0.015-4 | 2 | 4 (100.0) | 93.1 |
| Caspofungin | 1,238 | 0.015-4 | 0.25 | 1 (98.6) | 99.9 | |
| Micafungin | 1,238 | 0.015-2 | 1 | 4 (100) | 100.0 | |
| C. guilliermondii | Anidulafungin | 88 | 0.06-4 | 2 | 16 (100.0) | 92.0 |
| Caspofungin | 88 | 0.03->8 | 0.5 | 4 (95.5) | 95.5 | |
| Micafungin | 88 | 0.015->8 | 0.5 | 4 (98.9) | 98.9 | |
a
Percentage of isolates for which MIC is less than or equal to the ECV.