TABLE 4.
Correlation between genotype and patient characteristicsa
| Characteristic | Amino acid(s)b or no. of mutations | Genderc |
Aged | No. of people | P value | ||
|---|---|---|---|---|---|---|---|
| No. (%) male | No. (%) female | P valueg | |||||
| pfcrt | 76K | 58 (63.7) | 40 (57.1) | 17.3 ± 14.5 | 98 | ||
| 76T | 33 (36.3) | 30 (42.9) | 0.4 | 25.7 ± 15.0 | 63 | <0.01h | |
| pfmdr1 | NYSNDe | 63 (86.3) | 55 (88.7) | 19.0 ± 15.1 | 118 | ||
| NFSND | 1 (1.4) | 4 (6.5) | 10.6 ± 6.5 | 5 | |||
| NYSDD | 2 (2.7) | 0 (0) | 22.5 ± 7.8 | 2 | |||
| NFSDD | 7 (9.6) | 3 (4.8) | 0.16 | 22.5 ± 14.5 | 10 | 0.1i | |
| pfdhfr + pfdhps | ≥5f | 31 (79.5) | 27 (81.8) | 0.8 | |||
| ≥6 | 18 (46.2) | 20 (60.0) | 0.22 | ||||
| ≥7 | 11 (28.2) | 14 (42.4) | 0.21 | ||||
a
Data for mixed infections were excluded.
b
Boldface type indicates amino acid mutations.
c
n = 91 for males, n = 70 for females.
d
The data are means ± standard deviations.
e
pfmdr1 positions 86, 184, 1034, 1042, and 1246, respectively.
f
The data represent the number of mutations for pfdhfr and pfdhps.
g
P values were obtained from analysis of relationships between gender and each genotype by the χ2 test.
h
Obtained from the t test for correlation between pfcrt genotypes and patient age.
i
Obtained by analysis of variance for correlation between pfmdr1 genotypes and patient age.