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. 2009 Nov 18;84(3):1387–1396. doi: 10.1128/JVI.01437-09

FIG. 1.

FIG. 1.

Vpx facilitates SIVmac and HIV-1 infection of MDM and PMA-differentiated THP-1 cells. (A) MDM and differentiated THP-1 cells were infected with VSV-G pseudotyped SIVmac luciferase reporter viruses normalized for infectivity. (B) Enhancement of SIV and HIV-1 infection of MDM by Vpx-containing VLP. Cells were preincubated with VLP for 2 h and then infected with SIV (left) or HIV-1 (right) reporter virus at a 10:1 ratio of VLP to virus. (C) Effect of VLP on SIV and HIV-1 infection of THP-1. THP-1 cells were preincubated with VLP and infected with reporter virus. (D) Effect of Vpx-containing VLP on HIV-1 infection of SUPT1 and HeLa cells. The cells were preincubated for 2 h with VLP and infected with HIV-1 reporter virus. The luciferase activity was measured 3 days postinfection for THP-1 or 4 days postinfection for MDM. The results shown are representative of results obtained with three independent experiments with different donor PBMC.