TABLE 2.
Association between virus characteristics and neutralization sensitivity
| Characteristicd | Difference in log ID50 (95% CI)a | P valueb |
|---|---|---|
| Stage | 0.0842 | |
| Early | 0.00 | |
| Chronic | 0.30 (−0.15, 0.75) | |
| Transmitted | 0.24 (0.03, 0.45) | |
| Source | 0.8120 | |
| Plasma | 0.00 | |
| ccPBMC | 0.05 (−0.15, 0.25) | |
| ucPBMC | −0.01 (−0.18, 0.15) | |
| Clade | 0.0019 | |
| B | 0.00 | |
| A | 0.26 (0.004, 0.52) | |
| C | 0.32 (−0.03, 0.66) | |
| CRF02_AGc | −0.28 (−0.59, 0.02) | |
| CRF07_BC | −0.42 (−0.70, −0.14) | |
| D | −0.20 (−0.46, 0.05) | |
| Virus/plasma clade match | 0.25 (0.19, 0.32) | <0.0001 |
a
Estimates are derived from a GEE model for log10 ID50 titers that includes all virus characteristics as covariates. For each characteristic, the estimated difference in mean log10 ID50 titers between each group and the reference group is shown. 95% CI, 95% confidence interval.
b
P values are based on generalized Wald tests.
c
CRF02_AG viruses include pure subtype and closely related CRF02 isolates, all from Cameroon (see Table 1 and Fig. 8).
d
ccPBMC, cocultured PBMC; ucPBMC, uncultured PBMC.